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Tocris Bioscience™ CEP 1347
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Catalog No. 49241
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49-241 1 mg
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Catalog No. 49-241 Supplier Tocris Bioscience™ Supplier No. 4924/1
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Description

Inhibitor of JNK signaling

CEP 1347 is a potent inhibitor of mixed lineage kinases MLK3, MLK1 and MLK2 (IC50 values in vitro are 23-39 nM, 38-61 nM and 51-82 nM, respectively), and blocks downstream c-jun N-terminal kinase (JNK) activation (IC50 = 20 nM). CEP 1347 rescues motor neurons undergoing apoptosis (EC50 = 20 nM), blocks Aβ-induced cortical neuron apoptosis (EC50 ∼51 nM) and, in an animal model of Huntington's disease, restores BDNF mRNA to wild type levels. CEP 1347 is orally bioavailable and brain penetrant.

Chemical Identifiers

CAS 156177-65-0
Molecular Formula C33H33N3O5S2

Specifications

Quantity 1 mg
Formula Weight 615.76
Molecular Weight (g/mol) 615.763
Chemical Name or Material CEP 1347

Safety and Handling

Recommended Storage Store at -20°C
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