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Invitrogen™ CEP135 Polyclonal Antibody
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Catalog No. PIPA536440
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100 μL
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PIPA536440 100 μL
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Catalog No. PIPA536440 Supplier Invitrogen™ Supplier No. PA536440
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 135 kDa. Purity is >95% by SDS-PAGE.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CEP135
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene CEP135
Gene Accession No. Q66GS9
Gene Alias BC062951; centrosomal protein 135; centrosomal protein 135kDa; centrosomal protein 4; Centrosomal protein of 135 kDa; centrosomal protein of 135 kDa; LOW QUALITY PROTEIN: centrosomal protein of 135 kDa; centrosome protein cep135; Cep135; Cep4; Gm1044; KIAA0635; MCPH8; RGD1310726
Gene Symbols CEP135
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 1087-1140 of human CEP135.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 305288, 9662
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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