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Invitrogen™ Cerebellin 4 Polyclonal Antibody
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Catalog No. PIPA536472
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PIPA536472 100 μL
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Catalog No. PIPA536472 Supplier Invitrogen™ Supplier No. PA536472
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 27 kDa. Purity is >95% by SDS-PAGE.

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cerebellin 4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene CBLN4
Gene Accession No. Q8BME9, Q9NTU7
Gene Alias AI848962; Cbln4; CBLNL1; cerebellin 4 precursor; cerebellin 4 precursor protein; cerebellin precursor-like 1; Cerebellin4; cerebellin-4; Cerebellin-like glycoprotein 1; UNQ718/PRO1382
Gene Symbols CBLN4
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 148-197 of human Cerebellin 4.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140689, 228942, 499947
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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