Invitrogen™ CETP Monoclonal Antibody (ATM192)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA1050

Catalog No. MA1050

Description

MA1-050 detects cholesteryl ester transfer protein (CETP) from human and rabbit tissues. MA1-050 has been successfully used in Western blot, immunoprecipitation, IF and ELISA protocols. By Western blot, this antibody detects a doublet at ~70 kDa from human serum representing CETP. This antibody can also be used to immunoprecipitate CETP activity from serum samples using protein G. The MA1-050 immunogen is a synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.

It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

Specifications

• Antigen: CETP
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: P11597, P22687
• Gene Symbols: CETP
• Immunogen: Synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rabbit
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: ATM192
• Conjugate: Unconjugated
• Gene: CETP
• Gene Alias: BPI fold containing family F; BPIFF; CETP; Cholesteryl ester transfer protein; cholesteryl ester transfer protein plasma; cholesteryl ester transfer protein, plasma; HDLCQ10; Lipid transfer protein I
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100327267, 1071
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid