CFTR Rabbit anti-Human, Mouse, Polyclonal, liquid, OriGene

Catalog No.	Quantity
50-168-4792	100 μL

Catalog No. 50-168-4792 Supplier OriGene Supplier No. TA890106

Description

Rabbit Polyclonal Antibody

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.

Specifications

• Antigen: CFTR
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene: CFTR
• Gene Accession No.: P13569, P26361
• Gene Alias: ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1
• Gene Symbols: Cftr
• Host Species: Rabbit
• Immunogen: Recombit protein of human CFTR
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1080, 12638
• Target Species: Human, Mouse
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG