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Invitrogen™ cGAS Monoclonal Antibody (HGAYN), eBioscience™
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Catalog No. 14515882
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100 μg
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Catalog No. Quantity
14-515-882 100 μg
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Catalog No. 14-515-882 Supplier Invitrogen™ Supplier No. 14515882
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Description

Mouse Monoclonal Antibody

Description: This HGAYN monoclonal antibody recognizes human cGAS. This antibody works on reduced lysates. Applications Reported: This HGAYN antibody has been reported for use in Western Blot analysis. Applications Tested: This HGAYN antibody has been tested by western blot of HeLa cell line. This may be used at less than or equal to 2 μg/mL.

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.
TRUSTED_SUSTAINABILITY

Specifications

Antigen cGAS
Applications Western Blot
Classification Monoclonal
Clone HGAYN
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CGAS
Gene Accession No. Q8N884
Gene Alias C6orf150; h-cGAS; MB21D1
Gene Symbols CGAS
Host Species Mouse
Immunogen E. coli-derived recombinant human cGAS protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 115004
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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