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Invitrogen™ cGAS Recombinant Rabbit Monoclonal Antibody (10H1L5)

Catalog No. 703149
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Catalog No. Quantity
70-314-9 100 μg
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Catalog No. 70-314-9 Supplier Invitrogen™ Supplier No. 703149
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Rat, Pig. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.
TRUSTED_SUSTAINABILITY

Specifications

Antigen cGAS
Applications Western Blot
Classification Recombinant Monoclonal
Clone 10H1L5
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene CGAS
Gene Accession No. Q8C6L5
Gene Alias C6orf150; h-cGAS; MB21D1
Gene Symbols CGAS
Host Species Rabbit
Immunogen Protein corresponding to mouse cGAS [aa147-aa507].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 214763
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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