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Apexbio Technology LLC CH5132799 1007207-67-1 100mg
Supplier: Apexbio Technology LLC B2183100
CH5132799 (CAS 1007207-67-1) is a selective inhibitor targeting class I phosphoinositide-3-kinases (PI3Ks) particularly PI3K It exhibits inhibitory activity against PI3K isoforms and with IC50 values of 14 nM 120 nM 500 nM and 36 nM respectively and shows negligible potency against class II/III PI3Ks mTOR and other protein kinases In vitro CH5132799 suppresses proliferation in cancer cell lines such as HCT116 KPL-4 T-47D and SK-OV-3 Oral administration in mouse xenograft models demonstrates tumor regression highlighting CH5132799 s utility in anticancer research targeting PI3K signaling pathways
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