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  6. CHCHD6 Rabbit anti-Human, Polyclonal, Proteintech 

CHCHD6 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501733007 Shop All Proteintech Group Inc Products
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50-173-3007 150 μL
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Catalog No. 50-173-3007 Supplier Proteintech Group Inc Supplier No. 206391AP150UL
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Description

Rabbit Polyclonal Antibody

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Specifications

Antigen CHCHD6
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CHCHD6
Gene Accession No. Q9BRQ6
Gene Alias CHCHD6, CHCM1, MIC25
Gene Symbols CHCHD6
Host Species Rabbit
Immunogen CHCHD6 Fusion Protein Ag14700
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84303
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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