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Invitrogen™ CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8)

Catalog No. 703595
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Catalog No. Quantity
70-359-5 100 μg
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Catalog No. 70-359-5 Supplier Invitrogen™ Supplier No. 703595
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Mouse, Rat, Bovine.

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHD8
Applications ChIP Assay, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 20H56L8
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene Chd8
Gene Accession No. Q9HCK8
Gene Alias 5830451P18Rik; ATP-dependent helicase CHD8; AU015341; AUTS18; Axis duplication inhibitor; beta-catenin binding protein; CHD8; CHD-8; chromodomain helicase DNA binding protein 8; chromodomain-helicase-DNA-binding protein 8; Duplin; helicase with SNF2 domain 1; HELSNF1; Kiaa1564; mKIAA1564
Gene Symbols Chd8
Host Species Rabbit
Immunogen Protein corresponding to human CHD8 [aa2291-aa2364].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57680
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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