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Invitrogen™ CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ 703595

Description
This antibody is predicted to react with Mouse, Rat, Bovine.
DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
Specifications
CHD8 | |
Recombinant Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q9HCK8 | |
Chd8 | |
Protein corresponding to human CHD8 [aa2291-aa2364]. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
ChIP Assay, Immunocytochemistry | |
20H56L8 | |
Unconjugated | |
Chd8 | |
5830451P18Rik; ATP-dependent helicase CHD8; AU015341; AUTS18; Axis duplication inhibitor; beta-catenin binding protein; CHD8; CHD-8; chromodomain helicase DNA binding protein 8; chromodomain-helicase-DNA-binding protein 8; Duplin; helicase with SNF2 domain 1; HELSNF1; Kiaa1564; mKIAA1564 | |
Rabbit | |
Protein A | |
RUO | |
57680 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
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