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Invitrogen™ CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 703595

Encompass_Preferred

Catalog No. 70-359-5


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Description

Description

This antibody is predicted to react with Mouse, Rat, Bovine.

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CHD8
Recombinant Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.4
Q9HCK8
Chd8
Protein corresponding to human CHD8 [aa2291-aa2364].
100 μg
Primary
Human
Antibody
IgG
ChIP Assay, Immunocytochemistry
20H56L8
Unconjugated
Chd8
5830451P18Rik; ATP-dependent helicase CHD8; AU015341; AUTS18; Axis duplication inhibitor; beta-catenin binding protein; CHD8; CHD-8; chromodomain helicase DNA binding protein 8; chromodomain-helicase-DNA-binding protein 8; Duplin; helicase with SNF2 domain 1; HELSNF1; Kiaa1564; mKIAA1564
Rabbit
Protein A
RUO
57680
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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