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Apexbio Technology LLC CHIR-99021 (CT99021) 252917-06-9 10mg
Supplier: Apexbio Technology LLC A301110
CHIR-99021 (CT99021 CAS 252917-06-9) is a selective inhibitor of glycogen synthase kinase-3 (GSK-3) targeting both isoforms GSK-3 and GSK-3 with IC50 values of approximately 10 nM and 6 7 nM respectively Through inhibition of GSK-3 CHIR-99021 stabilizes downstream factors like -catenin and c-Myc supporting pluripotency and self-renewal in mouse embryonic stem (ES) cells such as B6 BALB/c and J1 mESC lines Additionally its use influences signaling pathways including Wnt/ -catenin TGF- /Nodal and MAPK and modulates epigenetic regulators like Dnmt3l impacting differentiation and proliferation processes in thymocytes
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