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Invitrogen™ Chk1 Monoclonal Antibody (DCS-310)
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Catalog No. PIMA191087 Shop All Thermo Scientific Products
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100 μg
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PIMA191087 100 μg
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Catalog No. PIMA191087 Supplier Invitrogen™ Supplier No. MA191087
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Description

Mouse Monoclonal Antibody

Heat in a microwave oven, twice for 10 minutes in citrate buffer, pH 6.5.

CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Chk1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone DCS-310
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Chek1
Gene Accession No. O14757, O35280, Q91ZN7
Gene Alias C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols Chek1
Host Species Mouse
Immunogen Recombinant full length protein (Human).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1111, 12649, 140583
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG3
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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