Chlorpromazine Hydrochloride, MP Biomedicals™

Description

Inhibits calmodulin-dependent stimulation. Chlorpromazine Hydrochloride, MP Biomedicals is a phenothiazine antipsychotic and a D2 and H1 antagonist. It is a substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of

Chlorpromazine Hydrochloride inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase, and it is reported to uncouple and inhibit oxidative phosphorylation at 10-3 – 10-4 M.

• Demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes
• Phenothiazine antipsychotic
• D2 dopamine and H1 histamine receptors antagonist
• Possibly a photo-genotoxic agent in humans
• Helps to induce hypothermia in mice in the dose range of 12.5–100mg/kg
• A substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase

Specifications

Chemical Identifiers

• CAS: 69-09-0
• Molecular Formula: C17H20Cl2N2S
• Molecular Weight (g/mol): 355.321
• InChI Key: FBSMERQALIEGJT-UHFFFAOYSA-N
• Synonym: chlorpromazine hydrochloride, sonazine, chlorpromazine hcl, chloractil, klorpromex, promacid, hebanil, propaphenin, hibernal, hybernal
• PubChem CID: 6240
• ChEBI: CHEBI:3649
• IUPAC Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
• SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl

• Melting Point: 194°C to 199°C
• Loss on Drying: ≤1.0%
• Quantity: 1 kg
• Solubility Information: Soluble in water (50mg/mL - clear, colorless to faint yellow-grey solution), methanol, ethanol, chloroform; practically insoluble in ether, benzene.
• Formula Weight: 355.3g/mol
• Physical Form: Powder

Safety and Handling

Recommended Storage

Store at Room Temperature (15–30°C)

WARNING: Reproductive Harm - www.P65Warnings.ca.gov