Chlortetracycline hydrochloride, specified according to the requirements of Ph.Eur., Thermo Scientific Chemicals

Description

Chlortetracycline hydrochloride, CAS # 64-72-2, is a broad-spectrum antibiotic of the tetracycline family.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General features
• Chlortetracycline hydrochloride is a broad-spectrum antibiotic of the tetracycline family
• Receives its name from a 7-chloro substitution on one of the rings of its parent structure, tetracycline
• A bacteriostatic that inhibits the 30S ribosomal subunit and prevents peptide formation
• Can work as an antiprotozoal and antifungal

Applications
• Chlortetracycline is suitable for use in biochemistry, microbiology, in vivo research, and cell culture
• Intended for research use only

Specifications

Chemical Identifiers

• CAS: 64-72-2
• Molecular Formula: C₂₂H₂₃ClN₂O₈·HCl
• Molecular Weight (g/mol): 515.33
• MDL Number: MFCD00082440
• InChI Key: QYAPHLRPFNSDNH-CIVPRPTRSA-N
• Synonym: chlortetracycline hydrochloride, 4-epi-chlortetracycline hydrochloride, 2-amino hydroxy methylidene-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride, 2-azanyl oxidanyl methylidene-7-chloranyl-4-dimethylamino-6-methyl-6,10,11,12a-tetrakis oxidanyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride
• PubChem CID: 66577600
• IUPAC Name: (4S,4aR,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
• SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O.Cl

• Absorbance: 0.40 max. (460nm)
• Melting Point: 220.0°C
• Color: Yellow
• pH: 2.3 to 3.3 (1% H₂O, CO₂ free)
• Infrared Spectrum: Authentic
• Packaging: Glass bottle
• Quantity: 5 g
• Merck Index: 15,2198
• Specific Rotation Condition: − 242.50 (20.00°C c=0.5,water)
• Specific Rotation: − 242.50
• Solubility Information: Solubility in water: 8.6g/L (28°C). Other solubilities: practically insoluble in acetone,ether,,chloroform,dioxane and propylene glycol,17.4g/L methanol (28°C),1.7g/L ethanol (28°C),soluble in solutions of alkali hydroxides and,carbonat
• Formula Weight: 515.33
• Percent Purity: 94.5 to 102.0% (sum of the contents of chlortetra cycline hydrochloride and tetracycline hydrochloride, dry substance), ≥89.5% (chlortetracycline hydrochloride, dry substance), 8% max. (tetracycline hydrochloride, dry substance)
• Physical Form: Powder
• Chemical Name or Material: Chlortetracycline hydrochloride

Safety and Handling

Hazard Category	GHS Signal Word: Warning
Hazard Statement	GHS H Statement Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation.
Precautionary Statement	GHS P Statement IF ON SKIN: Wash with plenty of soap and water. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,if present a
EINECSNumber	200-591-7

SDS

RUO – Research Use Only