Invitrogen™ CHP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575494

Catalog No. PIPA575494

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains four EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

Specifications

• Antigen: CHP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHP2
• Gene Alias: 2010110P09Rik; calcineurin B homologous protein 2; calcineurin like EF-hand protein 2; calcineurin-like EF hand protein 2; calcineurin-like EF-hand protein 2; Cbhp2; CHP2; chp-2; HCA520; hepatocellular carcinoma antigen gene 520; hepatocellular carcinoma-associated antigen 520; Hepatocellular carcinoma-associated antigen 520 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 308965, 63928, 70261
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43745, Q810D1, Q9D869
• Gene Symbols: CHP2
• Immunogen: Synthetic peptide corresponding to amino acids 146-191 of Human CHP2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov