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Invitrogen™ CHP2 Polyclonal Antibody
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Catalog No. FEPA5144854
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100 μL
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FEPA5144854 100 μL
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Catalog No. FEPA5144854 Supplier Invitrogen™ Supplier No. PA5144854
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RLHHRFRALD RNKKGYLSRM DLQQIG Antigen sequence identity: Mouse 77%; Rat 77%.

CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains four EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHP2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CHP2
Gene Accession No. O43745
Gene Alias 2010110P09Rik; calcineurin B homologous protein 2; calcineurin like EF-hand protein 2; calcineurin-like EF hand protein 2; calcineurin-like EF-hand protein 2; Cbhp2; CHP2; chp-2; HCA520; hepatocellular carcinoma antigen gene 520; hepatocellular carcinoma-associated antigen 520; Hepatocellular carcinoma-associated antigen 520 homolog
Gene Symbols CHP2
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 30-55. Recombinant protein control fragment (Product #RP-109801).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 63928
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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