CIITA Monoclonal Antibody (OTI7B12), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-4450	100 μL

Catalog No. 50-168-4450 Supplier OriGene Supplier No. TA812200

Description

Mouse Monoclonal Antibody

CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

Specifications

• Antigen: CIITA
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI7B12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: CIITA
• Gene Accession No.: P33076
• Gene Alias: C2TA, CIITAIV, MHC2TA, NLRA
• Gene Symbols: CIITA
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 414-724 of human CIITA produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4261
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1