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CIITA Monoclonal Antibody (OTI7B12), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA812200

Encompass_Preferred

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Catalog No. 50-168-4450


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Description

Description

CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
Specifications

Specifications

CIITA
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P33076
CIITA
Human recombit protein fragment corresponding to amino acids 414-724 of human CIITA produced in E.coli.
100 μL
Primary
Human
Antibody
IgG1
Western Blot
OTI7B12
Unconjugated
CIITA
C2TA, CIITAIV, MHC2TA, NLRA
Mouse
Affinity Chromatography
RUO
4261
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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