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  5. Tocris Bioscience™ Ciliobrevin A

Tocris Bioscience™ Ciliobrevin A
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Catalog No. 45295
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

Specifications

Chemical Name or Material 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
CAS 302803-72-1
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C17H9Cl2N3O2
Formula Weight Observed MW: 358.18
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