cis-4-Hydroxy-L-proline, 99%

Description

CAS: 618-27-9 | C5H9NO3 | 131.13 g/mol

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 618-27-9
• Molecular Formula: C5H9NO3
• Molecular Weight (g/mol): 131.13
• MDL Number: MFCD00064319,MFCD00064320
• InChI Key: PMMYEEVYMWASQN-IMJSIDKUSA-N
• Synonym: cis-4-hydroxy-l-proline, 2s,4s-4-hydroxypyrrolidine-2-carboxylic acid, l-hydroxyproline, l-allohydroxyproline, allo-4-hydroxy-l-proline, cis-4-hydroxyproline, 4s-4-hydroxy-l-proline, l-cis-4-hydroxyproline, l-allo-hydroxyproline, l-proline, 4-hydroxy-, 4s
• PubChem CID: 440015
• ChEBI: CHEBI:28397
• IUPAC Name: (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
• SMILES: O[C@@H]1CN[C@@H](C1)C(O)=O

• Melting Point: ∽250°C (decomposition)
• Solubility Information: Soluble in water.
• Quantity: 250 mg
• Formula Weight: 131.13
• Optical Rotation: −59° (c=2 in Water)
• Percent Purity: 99%
• Chemical Name or Material: cis-4-Hydroxy-L-proline

Safety and Handling

EINECSNumber	210-542-1
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only