CISD2 Monoclonal Antibody (OTI4F8), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-3351	100 μL

Catalog No. 50-168-3351 Supplier OriGene Supplier No. TA810357

Description

Mouse Monoclonal Antibody

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Specifications

• Antigen: CISD2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI4F8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: CISD2
• Gene Accession No.: Q8N5K1
• Gene Alias: ERIS, Miner1, NAF-1, WFS2, ZCD2
• Gene Symbols: CISD2
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human CISD2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 493856
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1