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Invitrogen™ CISD2 Polyclonal Antibody
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Catalog No. PIPA598689
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100 μg
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PIPA598689 100 μg
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Catalog No. PIPA598689 Supplier Invitrogen™ Supplier No. PA598689
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Description

Rabbit Polyclonal Antibody

CISD2 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), ELISA

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CISD2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene CISD2
Gene Accession No. Q8N5K1, Q9CQB5
Gene Alias 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; BcDNA:RE49709; CDGSH iron sulfur domain 2; CDGSH iron sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2 homolog; Cdgsh2; CG1458; CG1458-PA; cisd2; Cisd2-PA; dkey-162b23.1; Dmel\CG1458; Dmel_CG1458; dWFS2; endoplasmic reticulum intermembrane small protein; ERIS; Miner1; MitoNEET; mitoNEET related 1; mitoNEET-related 1 protein; NAF-1; nervous system overexpressed protein 70; nervous system over-expressed protein 70; Noxp70; Nutrient-deprivation autophagy factor-1; RE49709p; RGD1566242; RH38554p; WFS2; Zcd2; zgc:64148; zgc:64148 protein; zinc finger, CDGSH-type domain 2; zKM0001
Gene Symbols CISD2
Host Species Rabbit
Immunogen Recombinant Human CDGSH iron-sulfur domain-containing protein 2 protein (61-135AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 493856, 67006
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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