Invitrogen™ Claudin 14 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA19028

Catalog No. 01-674-612

Description

This antibody is predicted to react with bovine, canine, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Several transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: Claudin 14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLDN14
• Gene Alias: AI851731; claudin 14; claudin-14; CLDN14; DFNB29; UNQ777/PRO1571
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 23562
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O95500
• Gene Symbols: CLDN14
• Immunogen: Synthetic peptide corresponding to the C terminus amino acids SATHSGYRLNDYV (aa 227-239).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG