Claudin 18 Mouse anti-Human, Mouse, Clone: 5G7F2, Proteintech

Catalog No.	Quantity
50-173-6601	150 μL

Catalog No. 50-173-6601 Supplier Proteintech Group Inc Supplier No. 661671IG150UL

Description

Mouse Monoclonal Antibody

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.

Specifications

• Antigen: Claudin 18
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Monoclonal
• Clone: 5G7F2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CLDN18
• Gene Accession No.: P56856, P56857
• Gene Alias: claudin 18, CLDN18, SFTA5, SFTPJ
• Gene Symbols: CLDN18
• Host Species: Mouse
• Immunogen: Claudin 18 Fusion Protein Ag15517
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51208, 56492
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a