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Claudin 18 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 211261AP150UL

Description
Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.Specifications
Claudin 18 | |
Polyclonal | |
Unconjugated | |
CLDN18 | |
claudin 18, CLDN18, SFTA5, SFTPJ | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
315953, 51208, 56492 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
0.25 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P56856, P56857 | |
Cldn18 | |
Claudin 18 Fusion Protein Ag15517 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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