CLCN1 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-2185	150 μL

Catalog No. 50-173-2185 Supplier Proteintech Group Inc Supplier No. 185951AP150UL

Description

Rabbit Polyclonal Antibody

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dents disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.

Specifications

• Antigen: CLCN1
• Applications: ELISA
• Classification: Polyclonal
• Concentration: 0.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CLCN1
• Gene Accession No.: P35523
• Gene Alias: Chloride channel protein 1, ClC 1, CLC1, CLCN1
• Gene Symbols: CLCN1
• Host Species: Rabbit
• Immunogen: CLCN1 Fusion Protein Ag13336
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1180
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG