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Invitrogen™ CMIP Polyclonal Antibody
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Catalog No. PIPA566862
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PIPA566862 100 μL
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Catalog No. PIPA566862 Supplier Invitrogen™ Supplier No. PA566862
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RDQWFHSLQWK KKIYKYKKVL SNPSRWEVVL KEIRTLVDMA LTSPLQDDSI NQAPLEIVSK LLSENTNLTT QEHENIIVAI APLLENNH Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three Mint isoforms, Mint1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that mint3 does not interact with munc-18. Mint3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CMIP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CMIP
Gene Accession No. Q8IY22
Gene Alias 4933407C03Rik; 5830471E12Rik; AI314065; AI464126; c-Maf inducing protein; c-Maf-inducing protein; Cmip; c-Mip; Kiaa1694; RGD1306101; TCMIP; Tc-Mip; Truncated c-Maf-inducing protein
Gene Symbols CMIP
Host Species Rabbit
Immunogen Recombinant Human CMIP. Recombinant protein control fragment (Product #RP-105403).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80790
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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