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Invitrogen™ CML66 Polyclonal Antibody
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Catalog No. PIPA554716
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100 μL
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PIPA554716 100 μL
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Catalog No. PIPA554716 Supplier Invitrogen™ Supplier No. PA554716
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IKKNEGLTWP ELVIGDKQGE LIRDSAQCAA IAERLMHLTS EELNPNPDKE KPPCNAQELE ECDIFFEESS SLCRFDGNTL KTTHVVNLGS NQYL Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 96%.

CML66, also known as TSGA10 (Testis Specific Gene A10), is a gene located on chromosome 8q23 that encodes a broadly immunogenic tumor antigen. The gene is expressed in various leukemias and solid tumors but has restricted expression in normal tissues, being predominantly found in the testis and heart. The physiological function of CML66 remains unclear. However, its immunogenic properties, including the ability to elicit strong humoral immune responses, make it a potential target for cancer immunotherapy. Studies have identified cytotoxic T lymphocyte (CTL) epitopes derived from CML66, suggesting that TSGA10-targeted therapies could be feasible. Moreover, research into the gene has revealed the existence of different isoforms, such as CML66-L (long) and CML66-S (short), which may have distinct roles in tumorigenesis and immune response modulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CML66
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NUDCD1
Gene Accession No. Q96RS6
Gene Alias 4921532K09Rik; AA407246; AW260430; AW556235; chronic myelogenous leukemia tumor antigen 66; CML66; CML66-L; NudC domain containing 1; nudC domain-containing protein 1; Nudcd1; OVA66; RGD1310624; Tumor antigen CML66
Gene Symbols NUDCD1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CML66. Recombinant protein control fragment (Product #RP-93769).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362906, 84955
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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