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Invitrogen™ CNF1/CNF2 Monoclonal Antibody (JC4)
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Catalog No. 01676395
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100 μg
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Catalog No. Quantity
01-676-395 100 μg
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Catalog No. 01-676-395 Supplier Invitrogen™ Supplier No. MA140276
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Description

Mouse Monoclonal Antibody

MA1-40276 detects CNF1/CNF2 from E. coli samples. MA1-40276 has been successfully used in ELISA, functional assays and Western blot applications. The MA1-40276 immunogen is residues 169-191 of N-terminus of CNF1. Endotoxin <24 EU/mg.

Cytotoxic necrotizing factor type 1 and 2 (CNF1 & CNF2) belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho; however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CNF1/CNF2
Applications ELISA, Functional Assay, Western Blot
Classification Monoclonal
Clone JC4
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene Alias Cytotoxic necrotizing factor 1; Cytotoxic necrotizing factor 2
Host Species Mouse
Immunogen Residues 169-191 of N-terminus of CNF1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Bacteria
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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