CNOT4 Mouse anti-Human, Clone: OTI4C7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF504475

Catalog No. 50-166-2920

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.

Specifications

• Antigen: CNOT4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CNOT4
• Gene Alias: CLONE243, NOT4, NOT4H
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4850
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI4C7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O95628
• Gene Symbols: CNOT4
• Immunogen: Human recombit protein fragment corresponding to amino acids 190-455 of human CNOT4 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1