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Invitrogen™ COL11A1 Polyclonal Antibody
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Catalog No. PIPA568410
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PIPA568410 100 μL
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Catalog No. PIPA568410 Supplier Invitrogen™ Supplier No. PA568410
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Description

Rabbit Polyclonal Antibody

COL11A1 Polyclonal Antibody for IHC (P)

Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: a 1(XI), a 2(XI), and a 3(XI). a 3(XI) is a post-translational modification of a 1(II). a 1(V) can also be found instead of a 3(XI). Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines. Isoform expression can be tissue specific. Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COL11A1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene COL11A1
Gene Accession No. P12107
Gene Alias a1(XI) collagen; C530001D20Rik; cho; chondrodysplasia; CO11A1; COBA1; COL11A1; COLL6; Collagen alpha 1; collagen alpha-1(XI) chain; collagen type XI alpha 1 chain; collagen XI, alpha-1 polypeptide; collagen, type XI, alpha 1; pro-alpha1(XI) collagen; procollagen, type XI, alpha 1; STL2; STL3; XI chain precursor
Gene Symbols COL11A1
Host Species Rabbit
Immunogen Synthetic protein corresponding to internal residues of human COL11A1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1301
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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