Invitrogen™ Procollagen I N-Peptide Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535379

Catalog No. PIPA535379

Description

This antibody is predicted to react with most mammals, birds, amphibians and fish based on 100% sequence homology. This antibody contains enough material to conduct 10 mini-Western blots.

Procollagen type I N-terminal propeptide (P1NP) is a specific marker of bone formation, reflecting the synthesis of type I collagen, which constitutes the major part of the bone matrix. P1NP is derived during the conversion of procollagen to collagen, produced by osteoblasts during bone formation. Its primary clinical application lies in the diagnosis and monitoring of metabolic bone diseases, particularly osteoporosis. In osteoporotic patients, P1NP levels can predict bone mineral density (BMD) responses to treatments like teriparatide and romosozumab. Low serum levels of P1NP are indicative of a high risk of BMD loss, providing a valuable tool for premenopausal women with systemic lupus erythematosus (SLE) and other conditions affecting bone health.

Specifications

• Antigen: Procollagen I N-Peptide
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COL1A1
• Gene Alias: P1NP; Procollagen I N
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1277, 12842, 29393
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: ∼0.15 mg/mL
• Formulation: PBS with no preservative; pH 7.5
• Gene Accession No.: P02452, P02454, P11087
• Gene Symbols: COL1A1
• Immunogen: Synthetic peptide corresponding to amino acid residues specific to human collagen 1, alpha 1 propeptide conjugated to KLH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG