Invitrogen™ COL22A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555200

Catalog No. PIPA555200

Description

Immunogen sequence: LKEELEEIAS EPKSAHVFHV SDFNAIDKIR GKLRRRLCEN VLCPSVRVEG DRFKHTNGGT KEITGFDLMD LFSVKEILGK RENGAQSSYV RMG Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset of the collagen superfamily, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction which is present only at the tissue junctions of muscles, tendons, the heart, articular cartilage, and skin. A knockdown of the orthologous zebrafish gene induces a muscular dystrophy by disruption of the myotendinous junction.

Specifications

• Antigen: COL22A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COL22A1
• Gene Alias: 2310067L16Rik; C80743; COL22A1; Collagen alpha-1(XXII) chain; collagen type XXII alpha 1; collagen type XXII alpha 1 chain; collagen, type XXII, alpha 1; procollagen, type XXII, alpha 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 169044
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8NFW1
• Gene Symbols: COL22A1
• Immunogen: Recombinant protein corresponding to Human COL22A1. Recombinant protein control fragment (Product #RP-93895).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG