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Collagen Pan Polyclonal Antibody, Invitrogen™

Catalog No. PIPA185324
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PIPA185324 50 μg
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Catalog No. PIPA185324 Supplier Thermo Scientific Supplier No. PA185324

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.5 mL distilled water. PA1-85324 detects Collagen I,II,III,IV,V in human samples. Reactivity with collagens 1 and 2 is ∽70% as strong as that with 3-5. Reactivity with human fibronectin, albumin, and immunoglobulins is <0.5%. Rabbit anti Human collagen I/II/III/IV/V antibodyrecognizes multiple collagen types and exhibits the following reactivities in ELISA with both native and denaturated human collagen types: I & III 100%, IV & V 90%, II 80%, Human fibronectin, albumin and immunoglobulins all <0.5%.

Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "e;Glycine X Y"e; triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This preparation results in a native conformation of the protein. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the gene encoding collagen 1 are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Collagen Pan
Applications ELISA, Immunocytochemistry, Immunohistochemistry (Frozen)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation BBS with 1% dextran, 1% mannitol and no preservative; pH 7.5
Gene COL1A2
Gene Accession No. P02452, P02458, P02461, P02462, P05997, P08123, P08572, P20908, P25940, P29400, P53420, Q01955, Q14031
Gene Alias [a]3(IV); [a]4(IV); 1110014L14Rik; AA960264; AB collagen; AI325291; AI413331; alpha 1 type IV collagen; alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha1 (III) collagen; alpha-1 type 1 collagen; alpha-1 type I collagen; Alpha-1 type II collagen; alpha1(I) procollagen; alpha1(IV) collagen; alpha1(V) collagen; alpha-2 collagen type IV; alpha-2 type I collagen; alpha3(IV); ANFH; AOM; Arresten; arthroophthalmopathy, progressive (Stickler syndrome); ASLN; ATS; AW550625; BB116301; Bru; BSVD; CA44; CA54; canstatin; cartilage collagen; CG2A1A; Chondrocalcin; COL11A3; Col1a1; Col1a-1; Col1a2; Col1a-2; Col2; Col2a; COL2A1; Col2a-1; COL3A1; Col3a-1; COL4A1; Col4a-1; COL4A1 NC1 domain; Col4a2; Col4a-2; COL4A3; col4a4; COL4A5; COL4A6; COL5A1; Col5a2; COL5A3; Cola1; Cola-1; Cola2; Cola-2; COLIA1; Collagen 1; Collagen 2; Collagen 3; Collagen 4; Collagen 5; collagen alpha 1 (V); collagen alpha 1 chain type I; collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen alpha-1(II) chain; Collagen alpha-1(III) chain; collagen alpha-1(IV) chain; Collagen alpha-1(V) chain; collagen alpha-2(I) chain; Collagen alpha-2(IV) chain; collagen alpha-2(V) chain; Collagen alpha-3(IV) chain; collagen alpha-3(V) chain; Collagen alpha-4(IV) chain; collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen COL1A2; collagen I, alpha-2 polypeptide; collagen II, alpha-1 polypeptide; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 1; collagen type I alpha 2 chain; collagen type II (Col2A1) gene, enhancer region; collagen type II alpha 1 chain; collagen type III alpha 1 chain; collagen type IV alpha 1 chain; collagen type IV alpha 2; collagen type IV alpha 3 chain; collagen type IV alpha 4 chain; collagen type IV alpha 5 chain; collagen type IV alpha 6 chain; collagen type IV alpha3 chain; collagen type IV alpha5 chain; collagen type V alpha 1; collagen type V alpha 2 chain; collagen type V alpha 3; collagen, fetal; collagen, fetal membrane, A polypeptide; collagen, type 1, alpha 1; collagen, type I, alpha 1; collagen, type I, alpha 2; collagen, type II, alpha 1; collagen, type III, alpha 1; collagen, type IV, alpha 1; collagen, type IV, alpha 2; collagen, type IV, alpha 3; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; collagen, type V, alpha 1; collagen, type V, alpha 2; collagen, type V, alpha 3; collagen, type V, alpha 4; COLLII; CXDELq22.3; D230017N05; dA149D17.3; dA24A23.1; Del(8)44H; Del(8)Bru44H; Del1; DELXq22.3; DFNX6; disproportionate micromelia; dJ889N15.4 (Collagen Alpha 6(IV)); Dmm; E130010M05Rik; EDS4A; EDSC; Ehlers-Danlos syndrome type IV, autosomal dominant; Goodpasture antigen; ICH; Lpk; M100856; minisatellite 10w detected by probe MMS10; mKIAA4231; MMS10-W; Mov13; Mov-13; Ms10w; OI1; OI2; OI3; OI4; oim; osteogenesis imperfecta; pan Collagen; POREN2; pro-(alpha)3(V) collagen; pro-alpha-1 collagen type 1; pro-alpha1(V) collagen; Pro-alpha3(V); Procollagen II alpha 1; procollagen type I, alpha 1; procollagen type IV alpha 5; procollagen type IV alpha 6; procollagen type V alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1; procollagen, type I, alpha 2; procollagen, type II, alpha 1; procollagen, type III, alpha 1; procollagen, type IV, alpha 1; procollagen, type IV, alpha 2; procollagen, type IV, alpha 3; procollagen, type IV, alpha 4; procollagen, type IV, alpha 5; procollagen, type IV, alpha 6; procollagen, type V, alpha 1; procollagen, type V, alpha 2
Gene Symbols COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, COL5A1, COL5A2, COL5A3
Host Species Rabbit
Immunogen A mixture of human collagen 1-5 from human placenta.
Purification Method Affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1277, 1278, 1280, 1281, 1282, 1284, 1285, 1286, 1287, 1288, 1289, 1290, 50509
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG
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