Complement C3c Mouse anti-Human, Clone: 10-02A, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA528086

Catalog No. PIMA528086

Description

Complement C3 (C3) is synthesized as a single-chain pro-molecule (185kDa) that then suffers several post-translational modifications. Before being secreted as a mature protein, C3 is split into b-chain (645 residues and 70kDa) and a-chain (992 residues and 115 kDa) and forms a rare internal thioester bond. C3 plays a central role in the activation of all the three pathways of complement activation i.e. the classical, alternative, and lectin pathway. As C3 is the major complement component and participates in several stages of the immune response, its deficiency generally associated with higher susceptibility to severe bacterial infections and in some cases with autoimmune diseases such as systemic lupus erythematosus.

Specifications

• Antigen: Complement C3c
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: BBS with 0.1% sodium azide
• Gene Accession No.: P01024
• Gene Symbols: C3
• Immunogen: Human C3 from normal serum, highly purified by chromatography
• Purification Method: Protein A
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
• Clone: 10-02A
• Conjugate: Unconjugated
• Gene: C3
• Format: Liquid
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μg
• Storage Requirements: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Primary or Secondary: Primary
• Gene ID (Entrez): 718