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Invitrogen™ Complement C4c Monoclonal Antibody (10-12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA528087

Catalog No. PIMA528087


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Description

Description

This antibody recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated.

C4B may be involved in systemic lupus erythematosus (SLE). A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variations affecting the gene represented in this entry. Interindividual copy-number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Complement C4c
Monoclonal
1.15 mg/mL
BBS with <0.1% sodium azide
P0C0L5
C4B
Purified human C4c.
100 μg
Primary
Human
Antibody
IgG1
ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
10-12
Unconjugated
C4B
Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A; C4a anaphylatoxin; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; CH; Chido form of C4; CO4; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement component 4B (Chido blood group); CPAMD2; CPAMD3
Mouse
Protein A
RUO
100293534, 721
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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