Complement C4c Mouse anti-Human, Clone: 10-12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA528087

Catalog No. PIMA528087

Description

This antibody recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated.

C4B may be involved in systemic lupus erythematosus (SLE). A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variations affecting the gene represented in this entry. Interindividual copy-number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE.

Specifications

• Antigen: Complement C4c
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: BBS with 0.09% sodium azide
• Gene Accession No.: P0C0L5
• Gene Symbols: C4B
• Immunogen: Purified human C4c
• Purification Method: Protein A
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
• Clone: 10-12
• Conjugate: Unconjugated
• Gene: C4B
• Format: Liquid
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μg
• Storage Requirements: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Primary or Secondary: Primary
• Gene ID (Entrez): 721