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Invitrogen™ Complement C5b-9 Monoclonal Antibody (3R2/0)
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Catalog No. PIMA528502
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100 μg
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Catalog No. Quantity
PIMA528502 100 μg
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Catalog No. PIMA528502 Supplier Invitrogen™ Supplier No. MA528502
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Description

Mouse Monoclonal Antibody

This antibody recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex.

The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement C5b-9
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 3R2/0
Concentration 1.093 mg/mL
Conjugate Unconjugated
Formulation BBS with <0.1% sodium azide
Gene C7
Gene Accession No. P01031, P02748, P10643, P13671
Gene Alias C5b-9; MAC Complex; Membrane Attack Complex
Gene Symbols C5, C6, C7, C9
Host Species Mouse
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 727, 729, 730, 735
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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