Invitrogen™ Complement C5b Monoclonal Antibody (aE11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ DIA0110102

Catalog No. DIA0110102

Description

DIA 011-01-02 binds both membrane-bound MAC and fluid-phase SC5b-9 complexes from human, porcine, baboon and equine samples. DIA 011-01-02 has been successfully used in ELISA and IHC applications. This antibody is not recommended for Western blotting as the epitope is destroyed during the process.

C5b-9 is also known as the TCC. TCC consists of C5b, C6, C7, C8 and C9. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The complex contains neoantigens that are absent from the individual native components and the monoclonal antibody DIA 011-01 is directed against a neoepitope exposed in C9 when incorporated into TCC.

Specifications

• Antigen: Complement C5b
• Classification: Monoclonal
• Concentration: 1.04 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P01031, P01032
• Gene Symbols: C5
• Immunogen: Purified C5b-9.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Monkey, Pig, Horse
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Clone: aE11
• Conjugate: Unconjugated
• Gene: C5
• Gene Alias: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5; C5a; C5a anaphylatoxin; C5b; C5D; CHE1; complement C5; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain; complement C5a anaphylatoxin; complement component 5; complement component C5; CPAMD4; ECLZB; FLJ17816; FLJ17822; MGC142298; prepro-C5
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100067655, 414437, 727
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov