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Invitrogen™ Complement C9 Polyclonal Antibody
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Catalog No. PIPA529093
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100 μL
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PIPA529093 100 μL
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Catalog No. PIPA529093 Supplier Invitrogen™ Supplier No. PA529093
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: THP-1, BCL-1, human plasma. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement C9
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.62 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene C9
Gene Accession No. P02748, P06683, Q62930
Gene Alias ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor
Gene Symbols C9
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human C9. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117512, 12279, 735
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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