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Invitrogen™ Complement Factor Ba Monoclonal Antibody (014III-33.2.4.3)
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Catalog No. PIMA528083
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100 μL
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PIMA528083 100 μL
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Catalog No. PIMA528083 Supplier Invitrogen™ Supplier No. MA528083
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Description

Mouse Monoclonal Antibody

This antibody Mouse anti Human Complement Factor B (Ba Fragment) antibody, clone 014III-33.2.4.3 recognizes the 30 kDa Ba fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change.

CFB is involved in hemolytic uremic syndrome atypical 4 (AHUS4), an atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement Factor Ba
Applications ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 014III-33.2.4.3
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.1% sodium azide
Gene CFB
Gene Accession No. P00751
Gene Alias AHUS4; ARMD14; BF; B-factor, properdin; BFD; C3 proaccelerator; C3 proactivator; C3/C5 convertase; CFAB; CFB; CFBD; complement factor B; Complement factor B Ba fragment; Complement factor B Bb fragment; FB; FBI12; GBG; Glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein; H2-Bf; PBF2; Properdin factor B
Gene Symbols CFB
Host Species Mouse
Immunogen Purified human complement factor b.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 629
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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