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Complement Factor Ba Mouse anti-Human, Clone: 014III-33.2.4.3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA528083

Catalog No. PIMA528083


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Description

Description

This antibody Mouse anti Human Complement Factor B (Ba Fragment) antibody, clone 014III-33.2.4.3 recognizes the 30 kDa Ba fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change.

CFB is involved in hemolytic uremic syndrome atypical 4 (AHUS4), an atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Specifications

Specifications

Complement Factor Ba
Monoclonal
1 mg/mL
BBS with 0.1% sodium azide
P00751
CFB
Purified human complement factor b
Protein A
RUO
Antibody
Monoclonal
Human
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot
014III-33.2.4.3
Unconjugated
CFB
Liquid
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
629
Documents
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