Compound 401, Tocris Bioscience™

Description

Selective DNA-PK and mTOR inhibitor

Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.

Specifications

Chemical Identifiers

• CAS: 168425-64-7
• Molecular Formula: C16H15N3O2
• Molecular Weight (g/mol): 281.315
• InChI Key: BVRDQVRQVGRNHG-UHFFFAOYSA-N
• PubChem CID: 10039361
• IUPAC Name: 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one
• SMILES: C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2

• Quantity: 50 mg
• Synonym: compound 401, 2-morpholino-4h-pyrimido 2,1-a isoquinolin-4-one, 2-morpholin-4-yl pyrimido 2,1-a isoquinolin-4-one, 2-morpholin-4-yl-pyrimido 2,1-a isoquinolin-4-one, 2-4-morpholinyl-4h-pyrimido 2,1-a isoquinolin-4-one, compound401, d0t0by, 2-morpholin-1-yl pyrimido 2,1-a isoquinolin-4-one
• Formula Weight: 281.31
• Percent Purity: >99%
• Chemical Name or Material: Compound 401

Safety and Handling

Recommended Storage

Store at Room Temperature