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Compound 401, Tocris Bioscience™

Catalog No. 327150
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Quantity:
50 mg
Catalog No. Quantity
32-715-0 50 mg
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Catalog No. 32-715-0

Supplier: R&D Systems 3271/50

This item is not returnable. View return policy

Description

Selective DNA-PK and mTOR inhibitor

Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.

Chemical Identifiers

CAS 168425-64-7
Molecular Formula C16H15N3O2
Molecular Weight (g/mol) 281.315
InChI Key BVRDQVRQVGRNHG-UHFFFAOYSA-N
PubChem CID 10039361
IUPAC Name 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one
SMILES C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2

Specifications

Quantity 50 mg
Synonym compound 401, 2-morpholino-4h-pyrimido 2,1-a isoquinolin-4-one, 2-morpholin-4-yl pyrimido 2,1-a isoquinolin-4-one, 2-morpholin-4-yl-pyrimido 2,1-a isoquinolin-4-one, 2-4-morpholinyl-4h-pyrimido 2,1-a isoquinolin-4-one, compound401, d0t0by, 2-morpholin-1-yl pyrimido 2,1-a isoquinolin-4-one
Formula Weight 281.31
Percent Purity >99%
Chemical Name or Material Compound 401

Safety and Handling

Recommended Storage Store at Room Temperature
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