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Invitrogen™ COMT Polyclonal Antibody
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Catalog No. PIPA518330
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100 μg
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PIPA518330 100 μg
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Catalog No. PIPA518330 Supplier Invitrogen™ Supplier No. PA518330
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COMT
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Comt
Gene Accession No. P21964
Gene Alias Catechol O-methyltransferase; catecholamine-O-methyltransferase; catechol-O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; Comt; Comt1; D16Wsu103e; D330014B15Rik; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
Gene Symbols Comt
Host Species Goat
Immunogen Synthetic peptide sequence (GDTKEQRILNHVLQC) corresponding to the N-terminus amino acids of COMT (aa 52-62).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1312
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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