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Invitrogen™ Connexin 31 Polyclonal Antibody
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Catalog No. 365100
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100 μg
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Catalog No. Quantity
36-510-0 100 μg
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Catalog No. 36-510-0 Supplier Invitrogen™ Supplier No. 365100
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Description

Rabbit Polyclonal Antibody

This antibody reacts with the ~32 kDa mouse Connexin 31 on Western blots; the band observed at ~62 kDa is probably due to dimerization of Connexin 31. Several higher bands of unknown origin are observed in western blots of mouse skin homogenates.

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Connexin 31
Applications Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene GJB3
Gene Accession No. O75712, P28231
Gene Alias Cnx31; connexin 31; connexin-31; Cx31; Cxn-31; D4Wsu144e; DFNA2; DFNA2B; EKV; Gap junction beta-3 protein; gap junction membrane channel protein beta 3; gap junction protein beta 3; gap junction protein, beta 3; gap junction protein, beta 3, 31kDa; Gjb3; Gjb-3
Gene Symbols GJB3
Host Species Rabbit
Immunogen Synthetic peptide derived from the C-terminal region of mouse connexin 31 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14620, 2707
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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