Invitrogen™ COP1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5141993

Catalog No. PIPA5141993

Description

Additional Information: This antibody is expected to recognize isoform 2 (NP_443121.1) only. In addition there may be cross-reaction with INCA (GeneID 440068; NP_001007233.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt].

Specifications

• Antigen: COP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD16
• Gene Alias: CARD only domain-containing protein 1; CARD only protein; CARD16; CARD-only protein 1; caspase recruitment domain family member 16; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; caspase-1 inhibitor COP; Constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; COP; COP1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; hCOP1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; PSEUDO-ICE; pseudo-IL1B-converting enzyme; putative ubiquitin ligase COP1; RFWD2; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2; RNF200
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 114769
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q5EG05
• Gene Symbols: CARD16
• Immunogen: Peptide with sequence C-ETLGLSAGPIPGN.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG