Invitrogen™ COX1 Polyclonal Antibody

Catalog No.	Quantity
PIPA595171	100 μg

Catalog No. PIPA595171 Supplier Invitrogen™ Supplier No. PA595171

Description

Rabbit Polyclonal Antibody

Human COX1 shares 90% and 89% amino acid (aa) sequence identity with mouse and ratCOX1, respectively. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human HepG2 whole cell, human A431 whole cell, rat L6 whole cell, mouse C2C12 whole cell. IHC: human breast cancer tissue, human colonic adenoma tissue, human lung cancer tissue, mouse colon tissue, rat colon tissue. Flow: HEL cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

Specifications

• Antigen: COX1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: PTGS1
• Gene Accession No.: P22437, P23219, Q63921
• Gene Alias: COI; COX1; Cox-1; COX3; Cox-3; COXI; cyclooxygenase 3; cyclooxygenase precursor (EC 1.14.99.1); cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; Mtco1; mt-Co1; P PGG/HS; PCOX1; PES-1; PGG/HS; PGH synthase 1; PGHS1; Pghs-1; PHS 1; PHS1; prostaglandin endoperoxide synthase; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin G/H synthase precursor (EC 1.14.99.1); prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; unnamed protein product
• Gene Symbols: COX1, PTGS1
• Host Species: Rabbit
• Immunogen: E.coli-derived human COX1 recombinant protein (Position: E318-L599).
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19224, 24693, 4512, 5742
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov