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Apexbio Technology LLC CP-91149(Synonyms: CP91149, CP 91149, Glycogen Phosphorylase Inhibitor CP-91149, GP inhibitor CP-91149), 25mg, CAS: 186392-40-5.
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Supplier:  Apexbio Technology LLC A840325

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CP-91149 (CAS 186392-40-5) is a selective inhibitor of glycogen phosphorylase (GP) an enzyme responsible for catalyzing glycogen breakdown into glucose-1-phosphate by cleavage of terminal -1 4-glycosidic bonds CP-91149 inhibits GP with an IC50 of 0 13 M In cell assays using primary human hepatocytes and isolated rat hepatocytes this inhibitor reduces glucagon-stimulated glycogenolysis (IC50 2 1 M and 10-100 M respectively) activates glycogen synthase and induces protein redistribution from soluble to particulate fractions mimicking insulin effects In vivo (ob/ob diabetic mice) CP-91149 treatment at 25 50 mg/kg rapidly decreases blood glucose without affecting normoglycemic animals underscoring its relevance in diabetes research

Catalog No. 50-000-60052


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