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CRACR2A Mouse anti-Human, Clone: 4C1F5, Proteintech
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Catalog No. 501737188 Shop All Proteintech Group Inc Products
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50-173-7188 150 μL
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Catalog No. 50-173-7188 Supplier Proteintech Group Inc Supplier No. 667871IG150UL
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Description

Mouse Monoclonal Antibody

This antibody recognizes both of CRACR2A-c and CRACR2A-a.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Specifications

Antigen CRACR2A
Applications Western Blot
Classification Monoclonal
Clone 4C1F5
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CRACR2A
Gene Accession No. Q9BSW2
Gene Alias CRAC channel regulator 2A, CRACR2A, DKFZp686G13246, EFCAB4B, FLJ33046, FLJ33805
Gene Symbols CRACR2A
Host Species Mouse
Immunogen CRACR2A Fusion Protein Ag7525
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84766
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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