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Invitrogen™ CRALBP Monoclonal Antibody (B2)
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Catalog No. MA1813
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100 μg
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MA1813 100 μg
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Description

Mouse Monoclonal Antibody

MA1-813 detects CRALBP protein in bovine, human, mouse, non-human primate and rat samples. MA1-813 has successfully been used in Western blot, immunohistochemistry, immunoprecipitation, and immunofluorescence procedures. By Western blot, this antibody detects a 37 kDa protein representing human recombinant CRALBP. The MA1-813 immunogen is purified human recombinant CRALBP.

Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRALBP
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone B2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene RLBP1
Gene Accession No. P10123, P12271, Q9Z275
Gene Alias 3110056M11Rik; cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; CRALBP; retinaldehyde binding protein 1; retinaldehyde-binding protein 1; retinaldehyde-binding protein precursor; Rlbp1
Gene Symbols RLBP1
Host Species Mouse
Immunogen Human recombinant CRALBP.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19771, 282038, 293049, 6017
Target Species Human, Mouse, Rat, Monkey, Bovine
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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