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Invitrogen™ CRBN Recombinant Rabbit Monoclonal Antibody (PSH0-69)
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Catalog No. FERMA549359 Shop All Thermo Scientific Products
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FERMA549359 100 μL
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Catalog No. FERMA549359 Supplier Invitrogen™ Supplier No. MA549359
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Description

Rabbit Recombinant Monoclonal Antibody

Sequence Similarities: 95% Mouse/Rat. Tissue Specificity: Widely expressed. Highly expressed in brain. Positive Control: HEK-293 cell lysate, A375 cell lysate, A549 cell lysate, HeLa cell lysate, SH-SY5Y cell lysate, NIH/3T3 cell lysate, MCF7 cell lysate, mouse brain tissue lysate, rat testis tissue lysate, human testis tissue, human brain tissue. Subcellular Location: Cytoplasm, Nucleus, Membrane. Predicted band size: 51 kDa.

CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.
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Specifications

Antigen CRBN
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone PSH0-69
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene CRBN
Gene Accession No. Q56AP7, Q8C7D2, Q96SW2
Gene Alias 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; novel lethal; piL; protein cereblon; Protein PiL; protein x 0001
Gene Symbols CRBN
Host Species Rabbit
Immunogen Recombinant protein within human crbn aa 1-442 / 442.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 297498, 51185, 58799
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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