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TARGETMOL CHEMICALS INC CREBINOSTAT 5MG

Supplier: TARGETMOL CHEMICALS INC T270835MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Crebinostat is a potent histone deacetylase (HDAC) inhibitor inhibiting HDAC1 HDAC2 HDAC3 and HDAC6 with IC50s of 0.7 nM 1.0 nM 2.0 nM and 9.3 nM respectively.Crebinostat increases the density of synapsin-1 punctae along dendrites in neurons in vitro. Crebinostat increased the density of synapsin-1 punctae along dendrites in neurons in vitro. crebinostat modulated chromatin-mediated neuroplasticity and enhanced memory in mice. crebinostat induced histone H3 and histone H4 acetylation and enhanced the expression of the cAMP-responsive element binding protein (CREB) target gene Egr1. Crebinostat induces histone H3 and histone H4 acetylation and enhances the expression of Egr1 a cAMP response element binding protein (CREB) target. purity: 98%
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